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2017-07-05
17:00
[PUBDB-2017-06962] Journal Article
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RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments
ddc:570
The microtubule-associated protein tau is the main component of the paired helical filaments (PHFs) of Alzheimer's disease, the most common senile dementia. To understand the origin of tau's abnormal assembly we have studied the influence of other cytosolic components. [...]

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2017-07-05
16:50
[PUBDB-2017-06961] Journal Article
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Phosphorylation of Microtubule-associated Proteins MAP2 and MAP4 by the Protein Kinase p110$^{mark}$
ddc:570
The phosphorylation of microtubule-associated proteins (MAPs) is thought to be a key factor in the regulation of microtubule stability. We have shown recently that a novel protein kinase, termed p110 microtubule-affinity regulating kinase (“MARK”), phosphorylates microtubule-associated protein tau at the KXGS motifs in the region of internal repeats and causes the detachment of tau from microtubules (Drewes, G., Trinczek, B., Illenberger, S., Biernat, J., Schmitt-Ulms, G., Meyer, H. [...]

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2017-07-05
16:48
[PUBDB-2017-06960] Journal Article
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A Bayesian Approach to Laue Diffraction Analysis and its Potential for Time-Resolved Protein Crystallography
ddc:530
A solution to the energy-overlap problem in Lane diffraction is described that does not require redundancy in the measurements. The new method follows a Bayesian approach with multidimensional probability density functions. [...]

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2017-07-05
16:43
[PUBDB-2017-06959] Journal Article
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Nitric oxide oxidises a ferrous mammalian lipoxygenase to a pre-activated ferric species
ddc:570
Nitric oxide is known as an inhibitor of soybean lipoxygenase-1. Investigating the interaction of a mammalian 15-lipoxygenase with nitric oxide, we found that this enzyme is also inhibited reversibly when incubated with nitric oxide for a short time period (5 s) under anaerobic conditions. [...]

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2017-07-05
16:39
[PUBDB-2017-06958] Journal Article
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Physicochemical Characterization of Protein-Free Low Density Lipoprotein Models and Influence of Drug Loading
ddc:610
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2017-07-05
16:36
[PUBDB-2017-06957] Journal Article
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The 1.8 Å Resolution Structure of Hevamine, a Plant Chitinase/Lysozyme, and Analysis of the Conserved Sequence and Structure Motifs of Glycosyl Hydrolase Family 18
ddc:570
The three-dimensional structure of hevamine, a plant enzyme with chitinase and lysozyme activity, has been refined at 1.8 Å resolution to an R-factor of 14.9% and a freeR-factor of 19.6%. The final model consists of all 273 amino acid residues and 206 ordered water molecules. [...]

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2017-07-05
16:30
[PUBDB-2017-06956] Journal Article
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Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential
ddc:540
Drug carrier systems based on lipid nanosuspensions prepared by melt emulsification present a number of severe stability problems such as a high gelation tendency, considerable particle growth and drug expulsion. Destabilization of the emulsified lipidic carriers is related to recrystallization of the lipids. [...]

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2017-07-05
16:26
[PUBDB-2017-06955] Journal Article
; ; ; et al
The suitability of multi-metal clusters for phasing in crystallography of large macromolecular assemblies
ddc:570
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2017-07-05
15:59
[PUBDB-2017-06954] Journal Article
; ; ; et al
Crystal structure of bacteriophage T4 deoxynucleotide kinase with its substrates dGMP and ATP
The EMBO journal 15(14), 3487-3497 (1996)  GO
ddc:570
NMP kinases catalyse the phosphorylation of the canonical nucleotides to the corresponding diphosphates using ATP as a phosphate donor. Bacteriophage T4 deoxynucleotide kinase (DNK) is the only member of this family of enzymes that recognizes three structurally dissimilar nucleotides: dGMP, dTMP and 5-hydroxymethyl-dCMP while excluding dCMP and dAMP. [...]

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2017-07-05
15:51
[PUBDB-2017-06953] Journal Article
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New phases induced by sucrose in saturated phosphatidylethanolamines: an expanded lamellar gel phase and a cubic phase
ddc:570
A new lamellar gel phase (Lβ) with expanded lamellar period was found at low temperatures in dihexadecylphosphatidylethanolamine (DHPE) and dipalmitoylphosphatidylethanolamine (DPPE) dispersions in concentrated sucrose solutions (1–2.4 M). It forms via a cooperative, relatively broad transition upon cooling of the Lβ gel phase of these lipids. [...]

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